Processes for the synthesis of chloroadenosine and methylthioadenosine
An in situ process for preparing chloroadenosine is described, wherein adenosine in a non-aqueous solvent is reacted with a thionyl chloride and a pyridine to form a reaction solution; the non-aqueous solvent is exchanged with a lower alcohol, and a base is added to the reaction solution; and the re...
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| creator | SRIRANGAM JAYARAM KASTURI SAENZ JAMES EDWARD |
| description | An in situ process for preparing chloroadenosine is described, wherein adenosine in a non-aqueous solvent is reacted with a thionyl chloride and a pyridine to form a reaction solution; the non-aqueous solvent is exchanged with a lower alcohol, and a base is added to the reaction solution; and the resulting chloroadenosine is filtered, washed and dried. Additionally, a two-step process for the synthesis of methylthioadenosine using the chloroadenosine prepared in situ is described. |
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Additionally, a two-step process for the synthesis of methylthioadenosine using the chloroadenosine prepared in situ is described.</description><edition>7</edition><language>eng</language><subject>ALLOYS ; CASTING ; CASTING OF METALS ; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES ; CHEMISTRY ; DERIVATIVES THEREOF ; FERROUS OR NON-FERROUS ALLOYS ; METALLURGY ; MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; POWDER METALLURGY ; SUGARS ; TRANSPORTING ; TREATMENT OF ALLOYS OR NON-FERROUS METALS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030925&DB=EPODOC&CC=US&NR=2003181713A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030925&DB=EPODOC&CC=US&NR=2003181713A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SRIRANGAM JAYARAM KASTURI</creatorcontrib><creatorcontrib>SAENZ JAMES EDWARD</creatorcontrib><title>Processes for the synthesis of chloroadenosine and methylthioadenosine</title><description>An in situ process for preparing chloroadenosine is described, wherein adenosine in a non-aqueous solvent is reacted with a thionyl chloride and a pyridine to form a reaction solution; the non-aqueous solvent is exchanged with a lower alcohol, and a base is added to the reaction solution; and the resulting chloroadenosine is filtered, washed and dried. 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| subjects | ALLOYS CASTING CASTING OF METALS CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES CHEMISTRY DERIVATIVES THEREOF FERROUS OR NON-FERROUS ALLOYS METALLURGY MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL POWDER METALLURGY SUGARS TRANSPORTING TREATMENT OF ALLOYS OR NON-FERROUS METALS |
| title | Processes for the synthesis of chloroadenosine and methylthioadenosine |
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