Cell-based multiplexing ADME analysis using focused fluid flow
The invention relates to methods and devices for conducting multiplex assays for determining absorption, distribution, metabolism, and/or excretion (ADME) properties of an analyte. The method and device provide the ability to study analytes by controllably flowing, in laminar flow, an analyte in an...
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| creator | CHAO ANTHONY C KIRK MARTIN |
| description | The invention relates to methods and devices for conducting multiplex assays for determining absorption, distribution, metabolism, and/or excretion (ADME) properties of an analyte. The method and device provide the ability to study analytes by controllably flowing, in laminar flow, an analyte in an analyte stream over a substrate having a plurality of substantially parallel individual test lanes on the surface thereof, wherein each test lane comprises a plurality of living cells immobilized therein. Changes, when present, in the analyte, the cells, or both, are detected and thereafter correlated to an ADME property of the analyte. |
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The method and device provide the ability to study analytes by controllably flowing, in laminar flow, an analyte in an analyte stream over a substrate having a plurality of substantially parallel individual test lanes on the surface thereof, wherein each test lane comprises a plurality of living cells immobilized therein. 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| subjects | CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION TECHNICAL SUBJECTS COVERED BY FORMER USPC TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TRANSPORTING |
| title | Cell-based multiplexing ADME analysis using focused fluid flow |
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