Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors
Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | CARSTENSEN ELISABETH VANG SEHESTED MAXVELL CREIGHTON ANDREW JENSEN PETER BUHL SOKILDE BIRGITTE JENSEN LARS HOLLUND LANGER SEPPO W |
| description | Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2003032625A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2003032625A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2003032625A13</originalsourceid><addsrcrecordid>eNqNikEKwjAQRbNxIeodAq6FmKB7EcWuqzuhjMlIB9KkZKYFb29RD-Dq8d9_c3WvB-8pUUcBNaSgO4j4XQELjSA0In8eaZGKHnjqWEvuM3HusMAkqkp7EIgvIa8ptfQgyYWXavaEyLj6caHW59P1eNlgnxvkHjwmlOZWW2OccXZvd4et-696A78lPPc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors</title><source>esp@cenet</source><creator>CARSTENSEN ELISABETH VANG ; SEHESTED MAXVELL ; CREIGHTON ANDREW ; JENSEN PETER BUHL ; SOKILDE BIRGITTE ; JENSEN LARS HOLLUND ; LANGER SEPPO W</creator><creatorcontrib>CARSTENSEN ELISABETH VANG ; SEHESTED MAXVELL ; CREIGHTON ANDREW ; JENSEN PETER BUHL ; SOKILDE BIRGITTE ; JENSEN LARS HOLLUND ; LANGER SEPPO W</creatorcontrib><description>Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030213&DB=EPODOC&CC=US&NR=2003032625A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030213&DB=EPODOC&CC=US&NR=2003032625A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CARSTENSEN ELISABETH VANG</creatorcontrib><creatorcontrib>SEHESTED MAXVELL</creatorcontrib><creatorcontrib>CREIGHTON ANDREW</creatorcontrib><creatorcontrib>JENSEN PETER BUHL</creatorcontrib><creatorcontrib>SOKILDE BIRGITTE</creatorcontrib><creatorcontrib>JENSEN LARS HOLLUND</creatorcontrib><creatorcontrib>LANGER SEPPO W</creatorcontrib><title>Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors</title><description>Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNikEKwjAQRbNxIeodAq6FmKB7EcWuqzuhjMlIB9KkZKYFb29RD-Dq8d9_c3WvB-8pUUcBNaSgO4j4XQELjSA0In8eaZGKHnjqWEvuM3HusMAkqkp7EIgvIa8ptfQgyYWXavaEyLj6caHW59P1eNlgnxvkHjwmlOZWW2OccXZvd4et-696A78lPPc</recordid><startdate>20030213</startdate><enddate>20030213</enddate><creator>CARSTENSEN ELISABETH VANG</creator><creator>SEHESTED MAXVELL</creator><creator>CREIGHTON ANDREW</creator><creator>JENSEN PETER BUHL</creator><creator>SOKILDE BIRGITTE</creator><creator>JENSEN LARS HOLLUND</creator><creator>LANGER SEPPO W</creator><scope>EVB</scope></search><sort><creationdate>20030213</creationdate><title>Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors</title><author>CARSTENSEN ELISABETH VANG ; SEHESTED MAXVELL ; CREIGHTON ANDREW ; JENSEN PETER BUHL ; SOKILDE BIRGITTE ; JENSEN LARS HOLLUND ; LANGER SEPPO W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2003032625A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2003</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>CARSTENSEN ELISABETH VANG</creatorcontrib><creatorcontrib>SEHESTED MAXVELL</creatorcontrib><creatorcontrib>CREIGHTON ANDREW</creatorcontrib><creatorcontrib>JENSEN PETER BUHL</creatorcontrib><creatorcontrib>SOKILDE BIRGITTE</creatorcontrib><creatorcontrib>JENSEN LARS HOLLUND</creatorcontrib><creatorcontrib>LANGER SEPPO W</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CARSTENSEN ELISABETH VANG</au><au>SEHESTED MAXVELL</au><au>CREIGHTON ANDREW</au><au>JENSEN PETER BUHL</au><au>SOKILDE BIRGITTE</au><au>JENSEN LARS HOLLUND</au><au>LANGER SEPPO W</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors</title><date>2003-02-13</date><risdate>2003</risdate><abstract>Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2003032625A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T02%3A05%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CARSTENSEN%20ELISABETH%20VANG&rft.date=2003-02-13&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2003032625A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |