Bio-spectral imaging system and methods for diagnosing cell disease state
A bio-spectral imaging system and methods for in situ diagnosis of a disease state in biological tissue or cells of a living organism are provided. In one form, a method includes applying to the tissue or cells in situ a biological stain composition that includes at least one metachromatic dye; perf...
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| creator | LOREMAN DENNIS M COLLINS WILLIAM S CIPRIANI PIER J MALMROS MARK K |
| description | A bio-spectral imaging system and methods for in situ diagnosis of a disease state in biological tissue or cells of a living organism are provided. In one form, a method includes applying to the tissue or cells in situ a biological stain composition that includes at least one metachromatic dye; performing a spectral analysis to obtain at least one spectrum of the stained tissue or cells; comparing the spectrum with spectra from a library of spectra of similarly stained reference tissue or cells that have been categorized as diseased or non-diseased; and correlating the spectrum to a disease state. The system and methods may be used to diagnose, for example, pre-cancer and/or cancer, as well as diseases caused by various microorganisms. Methods for creating a library of spectra, methods for monitoring the efficiency of photodynamic therapy of diseased biological tissue or cells in vivo, as well as methods for improving the efficiency of photodynamic therapy are also provided. |
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In one form, a method includes applying to the tissue or cells in situ a biological stain composition that includes at least one metachromatic dye; performing a spectral analysis to obtain at least one spectrum of the stained tissue or cells; comparing the spectrum with spectra from a library of spectra of similarly stained reference tissue or cells that have been categorized as diseased or non-diseased; and correlating the spectrum to a disease state. The system and methods may be used to diagnose, for example, pre-cancer and/or cancer, as well as diseases caused by various microorganisms. Methods for creating a library of spectra, methods for monitoring the efficiency of photodynamic therapy of diseased biological tissue or cells in vivo, as well as methods for improving the efficiency of photodynamic therapy are also provided.</description><edition>7</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COLORIMETRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; DIAGNOSIS ; ELECTROTHERAPY ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; IDENTIFICATION ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MAGNETOTHERAPY ; MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT,POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED,VISIBLE OR ULTRA-VIOLET LIGHT ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; RADIATION PYROMETRY ; RADIATION THERAPY ; SPIRITS ; SURGERY ; TESTING ; ULTRASOUND THERAPY ; VINEGAR ; WINE</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030206&DB=EPODOC&CC=US&NR=2003026762A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030206&DB=EPODOC&CC=US&NR=2003026762A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LOREMAN DENNIS M</creatorcontrib><creatorcontrib>COLLINS WILLIAM S</creatorcontrib><creatorcontrib>CIPRIANI PIER J</creatorcontrib><creatorcontrib>MALMROS MARK K</creatorcontrib><title>Bio-spectral imaging system and methods for diagnosing cell disease state</title><description>A bio-spectral imaging system and methods for in situ diagnosis of a disease state in biological tissue or cells of a living organism are provided. 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| subjects | BEER BIOCHEMISTRY CHEMISTRY COLORIMETRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DIAGNOSIS ELECTROTHERAPY ENZYMOLOGY HUMAN NECESSITIES HYGIENE IDENTIFICATION INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MAGNETOTHERAPY MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT,POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED,VISIBLE OR ULTRA-VIOLET LIGHT MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS RADIATION PYROMETRY RADIATION THERAPY SPIRITS SURGERY TESTING ULTRASOUND THERAPY VINEGAR WINE |
| title | Bio-spectral imaging system and methods for diagnosing cell disease state |
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