Methods of treatment with anti-PACAP antibodies
The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies a...
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| creator | Rubin, Vanessa Lisbeth Dutzar, Benjamin H Scalley-Kim, Michelle Mulligan, Jenny Latham, John A Fan, Pei Allison, Daniel S Stewart, Erica Hendrix, Katherine Lee Karasek, Charlie Billgren, Jens J Loomis, Maria-Cristina Garcia-Martinez, Leon F Ojala, Ethan W Smith, Jeffrey T. L |
| description | The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications. |
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L</creator><creatorcontrib>Rubin, Vanessa Lisbeth ; Dutzar, Benjamin H ; Scalley-Kim, Michelle ; Mulligan, Jenny ; Latham, John A ; Fan, Pei ; Allison, Daniel S ; Stewart, Erica ; Hendrix, Katherine Lee ; Karasek, Charlie ; Billgren, Jens J ; Loomis, Maria-Cristina ; Garcia-Martinez, Leon F ; Ojala, Ethan W ; Smith, Jeffrey T. L</creatorcontrib><description>The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TESTING</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241210&DB=EPODOC&CC=US&NR=12162936B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241210&DB=EPODOC&CC=US&NR=12162936B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Rubin, Vanessa Lisbeth</creatorcontrib><creatorcontrib>Dutzar, Benjamin H</creatorcontrib><creatorcontrib>Scalley-Kim, Michelle</creatorcontrib><creatorcontrib>Mulligan, Jenny</creatorcontrib><creatorcontrib>Latham, John A</creatorcontrib><creatorcontrib>Fan, Pei</creatorcontrib><creatorcontrib>Allison, Daniel S</creatorcontrib><creatorcontrib>Stewart, Erica</creatorcontrib><creatorcontrib>Hendrix, Katherine Lee</creatorcontrib><creatorcontrib>Karasek, Charlie</creatorcontrib><creatorcontrib>Billgren, Jens J</creatorcontrib><creatorcontrib>Loomis, Maria-Cristina</creatorcontrib><creatorcontrib>Garcia-Martinez, Leon F</creatorcontrib><creatorcontrib>Ojala, Ethan W</creatorcontrib><creatorcontrib>Smith, Jeffrey T. L</creatorcontrib><title>Methods of treatment with anti-PACAP antibodies</title><description>The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND3TS3JyE8pVshPUygpSk0syU3NK1EozyzJUEjMK8nUDXB0dgwAM5PyUzJTi3kYWNMSc4pTeaE0N4Oim2uIs4duakF-fGpxQWJyal5qSXxosKGRoZmRpbGZk5ExMWoA8yYqfw</recordid><startdate>20241210</startdate><enddate>20241210</enddate><creator>Rubin, Vanessa Lisbeth</creator><creator>Dutzar, Benjamin H</creator><creator>Scalley-Kim, Michelle</creator><creator>Mulligan, Jenny</creator><creator>Latham, John A</creator><creator>Fan, Pei</creator><creator>Allison, Daniel S</creator><creator>Stewart, Erica</creator><creator>Hendrix, Katherine Lee</creator><creator>Karasek, Charlie</creator><creator>Billgren, Jens J</creator><creator>Loomis, Maria-Cristina</creator><creator>Garcia-Martinez, Leon F</creator><creator>Ojala, Ethan W</creator><creator>Smith, Jeffrey T. 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L</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Rubin, Vanessa Lisbeth</au><au>Dutzar, Benjamin H</au><au>Scalley-Kim, Michelle</au><au>Mulligan, Jenny</au><au>Latham, John A</au><au>Fan, Pei</au><au>Allison, Daniel S</au><au>Stewart, Erica</au><au>Hendrix, Katherine Lee</au><au>Karasek, Charlie</au><au>Billgren, Jens J</au><au>Loomis, Maria-Cristina</au><au>Garcia-Martinez, Leon F</au><au>Ojala, Ethan W</au><au>Smith, Jeffrey T. L</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Methods of treatment with anti-PACAP antibodies</title><date>2024-12-10</date><risdate>2024</risdate><abstract>The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING |
| title | Methods of treatment with anti-PACAP antibodies |
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