NLRP3 inflammasome inhibitors

The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical com...

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Bibliographische Detailangaben
Hauptverfasser:	Gommermann, Nina, Mattes, Henri, Mackay, Angela, Solovay, Catherine Fooks, Velcicky, Juraj, Farady, Christopher, Stiefl, Nikolaus Johannes, von Matt, Anette, Janser, Philipp, Smith, Nichola, Vangrevelinghe, Eric
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.