Highly potent ISVD compounds capable of substituting for FVIII(A)
The present invention provides ISVD polypeptide derivatives capable of binding coagulation Factor IX(a) and Factor X(a) which are highly potent and provide a sufficiently long half-life such to allow for effective subcutaneous-as well as peroral administration. The ISVD polypeptides derivatives disc...
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| creator | Bjelke, Jais Rose Steffensen, Soren Norrman, Mathias Hubalek, Frantisek Greisen, Per J Egebjerg, Thomas Granata, Daniele De Tavernier, Evelyn Fulle, Simone Lund, Jacob Buyse, Marie-Ange Vegge, Andreas Sassene, Philip Jonas |
| description | The present invention provides ISVD polypeptide derivatives capable of binding coagulation Factor IX(a) and Factor X(a) which are highly potent and provide a sufficiently long half-life such to allow for effective subcutaneous-as well as peroral administration. The ISVD polypeptides derivatives disclosed herein are thus suitable for treatment of haemophilia A, haemophilia A with inhibitors and acquired haemophilia A by various routes of administration including subcutaneous and peroral administration. |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Highly potent ISVD compounds capable of substituting for FVIII(A) |
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