Substituted piperazines as KRAS G12C inhibitors

Provided herein are KRAS G12C inhibitors, such ascomposition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

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Bibliographische Detailangaben
Hauptverfasser:	Amegadzie, Albert, Low, Jonathan D, Wurz, Ryan Paul, Lopez, Patricia, Wang, Hui-Ling, Xue, Qiufen, Nguyen, Thomas T, Chu-Moyer, Margaret, Walton, Mary, Chen, Jian, Ma, Vu Van, Goodman, Clifford, Booker, Shon, Reed, Anthony B, Cee, Victor J, Liu, Longbin, Shin, Youngsook, Minatti, Ana Elena, Lanman, Brian Alan, Chen, Ning, Pickrell, Alexander J, Siegmund, Aaron C, Allen, John Gordon, Allen, Jennifer Rebecca, Nishimura, Nobuko, Yang, Kevin C, Tamayo, Nuria A
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are KRAS G12C inhibitors, such ascomposition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.