Compounds and pharmaceutical compositions thereof for the treatment of diseases
The present invention discloses compounds according to Formula I:wherein R1, R2, R3a, R3b, X, Y1, Y2, Y3, and Z are as defined herein.The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, fo...
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| creator | Duthion, Béranger Alvey, Luke Jonathan Bonnaterre, Florence Marie-Emilie Temal-Laib, Taoues Tirera, Amynata Peixoto, Christophe Desroy, Nicolas Annoot, Denis Maurice Bucher, Denis Jary, Hélène Marie |
| description | The present invention discloses compounds according to Formula I:wherein R1, R2, R3a, R3b, X, Y1, Y2, Y3, and Z are as defined herein.The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of TNFα, interferons, IL-6, IL-12 and/or IL-23, respiratory diseases, endocrine and/or metabolic diseases, cardiovascular diseases, dermatological diseases, and/or abnormal angiogenesis associated diseases by administering the compound of the invention. |
| format | Patent |
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Alvey, Luke Jonathan ; Bonnaterre, Florence Marie-Emilie ; Temal-Laib, Taoues ; Tirera, Amynata ; Peixoto, Christophe ; Desroy, Nicolas ; Annoot, Denis Maurice ; Bucher, Denis ; Jary, Hélène Marie</creatorcontrib><description>The present invention discloses compounds according to Formula I:wherein R1, R2, R3a, R3b, X, Y1, Y2, Y3, and Z are as defined herein.The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of TNFα, interferons, IL-6, IL-12 and/or IL-23, respiratory diseases, endocrine and/or metabolic diseases, cardiovascular diseases, dermatological diseases, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240820&DB=EPODOC&CC=US&NR=12065443B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240820&DB=EPODOC&CC=US&NR=12065443B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Duthion, Béranger</creatorcontrib><creatorcontrib>Alvey, Luke Jonathan</creatorcontrib><creatorcontrib>Bonnaterre, Florence Marie-Emilie</creatorcontrib><creatorcontrib>Temal-Laib, Taoues</creatorcontrib><creatorcontrib>Tirera, Amynata</creatorcontrib><creatorcontrib>Peixoto, Christophe</creatorcontrib><creatorcontrib>Desroy, Nicolas</creatorcontrib><creatorcontrib>Annoot, Denis Maurice</creatorcontrib><creatorcontrib>Bucher, Denis</creatorcontrib><creatorcontrib>Jary, Hélène Marie</creatorcontrib><title>Compounds and pharmaceutical compositions thereof for the treatment of diseases</title><description>The present invention discloses compounds according to Formula I:wherein R1, R2, R3a, R3b, X, Y1, Y2, Y3, and Z are as defined herein.The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of TNFα, interferons, IL-6, IL-12 and/or IL-23, respiratory diseases, endocrine and/or metabolic diseases, cardiovascular diseases, dermatological diseases, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB3zs8tyC_NSylWSMxLUSjISCzKTUxOLS3JTE7MUUgGSRZnlmTm5xUrlGSkFqXmpymk5ReB2AolRamJJbmpeSUKQMGUzOLUxOLUYh4G1rTEnOJUXijNzaDo5hri7KGbWpAfn1pcADQ7L7UkPjTY0MjAzNTExNjJyJgYNQC6NjfA</recordid><startdate>20240820</startdate><enddate>20240820</enddate><creator>Duthion, Béranger</creator><creator>Alvey, Luke Jonathan</creator><creator>Bonnaterre, Florence Marie-Emilie</creator><creator>Temal-Laib, Taoues</creator><creator>Tirera, Amynata</creator><creator>Peixoto, Christophe</creator><creator>Desroy, Nicolas</creator><creator>Annoot, Denis Maurice</creator><creator>Bucher, Denis</creator><creator>Jary, Hélène Marie</creator><scope>EVB</scope></search><sort><creationdate>20240820</creationdate><title>Compounds and pharmaceutical compositions thereof for the treatment of diseases</title><author>Duthion, Béranger ; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Compounds and pharmaceutical compositions thereof for the treatment of diseases |
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