Pharmaceutical compounds for treatment of medical disorders
Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isola...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Chen, Dawei Wang, Qiuping Eastman, Kyle J Phadke, Avinash S Gadhachanda, Venkat Rao Greenlee, William Agarwal, Atul Wang, Xiangzhu Hashimoto, Akihiro Deshpande, Milind Wiles, Jason Allan Pais, Godwin Barrish, Joel Charles |
| description | Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US12006307B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US12006307B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US12006307B23</originalsourceid><addsrcrecordid>eNrjZLAOyEgsyk1MTi0tyUxOzFFIzs8tyC_NSylWSMsvUigpSk0syU3NK1HIT1PITU0BK0nJLM4vSkktKuZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBUBT81JL4kODDY0MDMyMDcydjIyJUQMA8U4wBQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Pharmaceutical compounds for treatment of medical disorders</title><source>esp@cenet</source><creator>Chen, Dawei ; Wang, Qiuping ; Eastman, Kyle J ; Phadke, Avinash S ; Gadhachanda, Venkat Rao ; Greenlee, William ; Agarwal, Atul ; Wang, Xiangzhu ; Hashimoto, Akihiro ; Deshpande, Milind ; Wiles, Jason Allan ; Pais, Godwin ; Barrish, Joel Charles</creator><creatorcontrib>Chen, Dawei ; Wang, Qiuping ; Eastman, Kyle J ; Phadke, Avinash S ; Gadhachanda, Venkat Rao ; Greenlee, William ; Agarwal, Atul ; Wang, Xiangzhu ; Hashimoto, Akihiro ; Deshpande, Milind ; Wiles, Jason Allan ; Pais, Godwin ; Barrish, Joel Charles</creatorcontrib><description>Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.</description><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240611&DB=EPODOC&CC=US&NR=12006307B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240611&DB=EPODOC&CC=US&NR=12006307B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Chen, Dawei</creatorcontrib><creatorcontrib>Wang, Qiuping</creatorcontrib><creatorcontrib>Eastman, Kyle J</creatorcontrib><creatorcontrib>Phadke, Avinash S</creatorcontrib><creatorcontrib>Gadhachanda, Venkat Rao</creatorcontrib><creatorcontrib>Greenlee, William</creatorcontrib><creatorcontrib>Agarwal, Atul</creatorcontrib><creatorcontrib>Wang, Xiangzhu</creatorcontrib><creatorcontrib>Hashimoto, Akihiro</creatorcontrib><creatorcontrib>Deshpande, Milind</creatorcontrib><creatorcontrib>Wiles, Jason Allan</creatorcontrib><creatorcontrib>Pais, Godwin</creatorcontrib><creatorcontrib>Barrish, Joel Charles</creatorcontrib><title>Pharmaceutical compounds for treatment of medical disorders</title><description>Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAOyEgsyk1MTi0tyUxOzFFIzs8tyC_NSylWSMsvUigpSk0syU3NK1HIT1PITU0BK0nJLM4vSkktKuZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBUBT81JL4kODDY0MDMyMDcydjIyJUQMA8U4wBQ</recordid><startdate>20240611</startdate><enddate>20240611</enddate><creator>Chen, Dawei</creator><creator>Wang, Qiuping</creator><creator>Eastman, Kyle J</creator><creator>Phadke, Avinash S</creator><creator>Gadhachanda, Venkat Rao</creator><creator>Greenlee, William</creator><creator>Agarwal, Atul</creator><creator>Wang, Xiangzhu</creator><creator>Hashimoto, Akihiro</creator><creator>Deshpande, Milind</creator><creator>Wiles, Jason Allan</creator><creator>Pais, Godwin</creator><creator>Barrish, Joel Charles</creator><scope>EVB</scope></search><sort><creationdate>20240611</creationdate><title>Pharmaceutical compounds for treatment of medical disorders</title><author>Chen, Dawei ; Wang, Qiuping ; Eastman, Kyle J ; Phadke, Avinash S ; Gadhachanda, Venkat Rao ; Greenlee, William ; Agarwal, Atul ; Wang, Xiangzhu ; Hashimoto, Akihiro ; Deshpande, Milind ; Wiles, Jason Allan ; Pais, Godwin ; Barrish, Joel Charles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US12006307B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2024</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Dawei</creatorcontrib><creatorcontrib>Wang, Qiuping</creatorcontrib><creatorcontrib>Eastman, Kyle J</creatorcontrib><creatorcontrib>Phadke, Avinash S</creatorcontrib><creatorcontrib>Gadhachanda, Venkat Rao</creatorcontrib><creatorcontrib>Greenlee, William</creatorcontrib><creatorcontrib>Agarwal, Atul</creatorcontrib><creatorcontrib>Wang, Xiangzhu</creatorcontrib><creatorcontrib>Hashimoto, Akihiro</creatorcontrib><creatorcontrib>Deshpande, Milind</creatorcontrib><creatorcontrib>Wiles, Jason Allan</creatorcontrib><creatorcontrib>Pais, Godwin</creatorcontrib><creatorcontrib>Barrish, Joel Charles</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chen, Dawei</au><au>Wang, Qiuping</au><au>Eastman, Kyle J</au><au>Phadke, Avinash S</au><au>Gadhachanda, Venkat Rao</au><au>Greenlee, William</au><au>Agarwal, Atul</au><au>Wang, Xiangzhu</au><au>Hashimoto, Akihiro</au><au>Deshpande, Milind</au><au>Wiles, Jason Allan</au><au>Pais, Godwin</au><au>Barrish, Joel Charles</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pharmaceutical compounds for treatment of medical disorders</title><date>2024-06-11</date><risdate>2024</risdate><abstract>Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US12006307B2 |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Pharmaceutical compounds for treatment of medical disorders |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T07%3A58%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Chen,%20Dawei&rft.date=2024-06-11&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS12006307B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |