Rapafucin derivative compounds and methods of use thereof

The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kumar, Puneet, Liu, Jun, Yamamoto, Kana, Semple, Joseph E, Hong, Sam, Sadagopan, Magesh, Ullman, Brett R, Schmitt, Jennifer C
Format: Patent
Sprache:eng
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