Artificial eye assembly for studying ocular pharmacokinetics

An artificial eye assembly (100) comprising: -an anterior layer (50) comprising an anterior cavity (52); -a flow constricting (40) layer comprising a first aperture (42), and wherein the first aperture (42) is in fluid communication with the anterior cavity (52); -a shaping layer (30) comprising a second aperture and a shaping structure (32), wherein the shaping structure (32) is located within, partially within, or outside of the second aperture, and wherein the shaping structure comprises (32) one or more webs (33), the webs (33) connecting the structure (32) to the rest of the shaping layer (30), and wherein the second aperture is in fluid communication with the first aperture (42); -a flow resistive layer (20) comprising pores, and wherein pores of the layer are in fluid communication with the second aperture; -a posterior layer (10) comprising a posterior cavity (12), and wherein the posterior cavity (12) is in fluid communication with pores of the flow resistive layer (20); -a fluid inlet (13) located in the anterior and/or posterior cavity (12, 52), or located in or adjacent to the second aperture; -a fluid outlet (54) located in the anterior cavity; and -an injection inlet (14) located in the posterior cavity and/or located in the anterior cavity, and wherein the anterior cavity (52) and the posterior cavity (12) are in fluid communication with one another via a fluid path formed through the layers (10, 20, 30, 40 50); and wherein, in use, a fluid introduced under pressure into the assembly via the fluid inlet (13) will flow along the fluid path and exit the assembly via the fluid outlet (54) with a first flow rate.