Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus

Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus

The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), sever...

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Bibliographische Detailangaben
Hauptverfasser: Denison, Mark R, Ahmed, Syed Kaleem, Tillotson, John Phillip, Sheahan, Timothy Patrick, Pathak, Ashish Kumar, Dutta, Shilpa, Augelli-Szafran, Corinne E, Baric, Ralph S, Sims, Amy Catherine, Moukha-Chafiq, Omar
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.