Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
Disclosed herein are compounds of formula (I)and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related...
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| creator | Kramer, James Bernard Maxey, Kirk M Uzieblo, Adam Endres, Gregory William Kornilov, Andriy Ciske, Fred Lawrence Colombo, Joseph Michael Barrett, Stephen Douglas Germain, Bradlee David |
| description | Disclosed herein are compounds of formula (I)and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders. |
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Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.</description><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>CHEMISTRY</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjTEOgkAQRWksjHqH8QAUIDHWKsbSRK3JZPejm8AO2RmsPLyYeACr37z3_jx7H0PbjZKkY2fck5N-kDF6JVaqLxUlOAwmKVd0cBZeIH5IDGpKrSQaFRQi2RNkCWw9opG0Xzfv4QMbPPmgYMUUjX66iD5YkKjLbNZyp1j9dpGtT_XtcM4xSAMd2CHCmvu1KHa7altW-3LzD_MB2zNHqQ</recordid><startdate>20240130</startdate><enddate>20240130</enddate><creator>Kramer, James Bernard</creator><creator>Maxey, Kirk M</creator><creator>Uzieblo, Adam</creator><creator>Endres, Gregory William</creator><creator>Kornilov, Andriy</creator><creator>Ciske, Fred Lawrence</creator><creator>Colombo, Joseph Michael</creator><creator>Barrett, Stephen Douglas</creator><creator>Germain, Bradlee David</creator><scope>EVB</scope></search><sort><creationdate>20240130</creationdate><title>Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions</title><author>Kramer, James Bernard ; Maxey, Kirk M ; Uzieblo, Adam ; Endres, Gregory William ; Kornilov, Andriy ; Ciske, Fred Lawrence ; Colombo, Joseph Michael ; Barrett, Stephen Douglas ; Germain, Bradlee David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US11884624B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2024</creationdate><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>CHEMISTRY</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Kramer, James Bernard</creatorcontrib><creatorcontrib>Maxey, Kirk M</creatorcontrib><creatorcontrib>Uzieblo, Adam</creatorcontrib><creatorcontrib>Endres, Gregory William</creatorcontrib><creatorcontrib>Kornilov, Andriy</creatorcontrib><creatorcontrib>Ciske, Fred Lawrence</creatorcontrib><creatorcontrib>Colombo, Joseph Michael</creatorcontrib><creatorcontrib>Barrett, Stephen Douglas</creatorcontrib><creatorcontrib>Germain, Bradlee David</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kramer, James Bernard</au><au>Maxey, Kirk M</au><au>Uzieblo, Adam</au><au>Endres, Gregory William</au><au>Kornilov, Andriy</au><au>Ciske, Fred Lawrence</au><au>Colombo, Joseph Michael</au><au>Barrett, Stephen Douglas</au><au>Germain, Bradlee David</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions</title><date>2024-01-30</date><risdate>2024</risdate><abstract>Disclosed herein are compounds of formula (I)and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions |
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