11,13-modified saxitoxins for the treatment of pain

11,13-modified saxitoxins for the treatment of pain

Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins...

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Hauptverfasser: Delwig, Anton, Pajouhesh, Hassan, Du Bois, Justin, Shibuya, Grant Masaaki, Beckley, Jacob, Mulcahy, John, Miljanich, George
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator Delwig, Anton
Pajouhesh, Hassan
Du Bois, Justin
Shibuya, Grant Masaaki
Beckley, Jacob
Mulcahy, John
Miljanich, George
description Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title 11,13-modified saxitoxins for the treatment of pain
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