Purification method and device for continuous distillation and separation of ibuprofen intermediate raw material
The present disclosure belongs to the technical field of chemical separation and purification, and in particular relates to a purification method and device for continuous distillation and separation of an ibuprofen intermediate raw material. The purification method comprises the following steps: ca...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Wang, Yinglong Cui, Peizhe Zhu, Zhaoyou Du, Deping Wang, Kaiguang Li, Xin Qi, Jianguang Xu, Wenhui Zheng, Zhonghui Zhong, Limei Jia, Jianbo |
| description | The present disclosure belongs to the technical field of chemical separation and purification, and in particular relates to a purification method and device for continuous distillation and separation of an ibuprofen intermediate raw material. The purification method comprises the following steps: carrying out a primary distillation on synthetic liquid to obtain a primary material and recovered 4-methyl-1-pentene, then carrying out a second-stage distillation on the primary material to obtain a second-stage material and a recovered crude toluene product; and carrying out a third-stage distillation on the second-stage material to obtain isobutyl benzene and a recovered crude n-butylbenzene product. Embodiment results show that the purification method provided by the present disclosure is high in product recovery rate and high in product purity, the purity of isobutyl benzene is up to 99.99 wt %, the recovery rate is up to 99.9 wt %, the impurity content is not higher than 50 ppm. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US11820743B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US11820743B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US11820743B13</originalsourceid><addsrcrecordid>eNqNyj0KAjEQhuFtLES9w3gAwXUFrRXFUlDrZUwmOJDMhPzo9VXWA1h97wfPuInnmtixwcIqEKg81AKKBUtPNgROExiVwlK1ZrCcC3s_6C_LFDENVx3wvcakjgRYCqVAlrEQJHxB-ERi9NNm5NBnmv120syPh-v-tKCoPeWIhoRKf7u07Xa13Ky7Xdv9Y97mVUR4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Purification method and device for continuous distillation and separation of ibuprofen intermediate raw material</title><source>esp@cenet</source><creator>Wang, Yinglong ; Cui, Peizhe ; Zhu, Zhaoyou ; Du, Deping ; Wang, Kaiguang ; Li, Xin ; Qi, Jianguang ; Xu, Wenhui ; Zheng, Zhonghui ; Zhong, Limei ; Jia, Jianbo</creator><creatorcontrib>Wang, Yinglong ; Cui, Peizhe ; Zhu, Zhaoyou ; Du, Deping ; Wang, Kaiguang ; Li, Xin ; Qi, Jianguang ; Xu, Wenhui ; Zheng, Zhonghui ; Zhong, Limei ; Jia, Jianbo</creatorcontrib><description>The present disclosure belongs to the technical field of chemical separation and purification, and in particular relates to a purification method and device for continuous distillation and separation of an ibuprofen intermediate raw material. The purification method comprises the following steps: carrying out a primary distillation on synthetic liquid to obtain a primary material and recovered 4-methyl-1-pentene, then carrying out a second-stage distillation on the primary material to obtain a second-stage material and a recovered crude toluene product; and carrying out a third-stage distillation on the second-stage material to obtain isobutyl benzene and a recovered crude n-butylbenzene product. Embodiment results show that the purification method provided by the present disclosure is high in product recovery rate and high in product purity, the purity of isobutyl benzene is up to 99.99 wt %, the recovery rate is up to 99.9 wt %, the impurity content is not higher than 50 ppm.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231121&DB=EPODOC&CC=US&NR=11820743B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231121&DB=EPODOC&CC=US&NR=11820743B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Wang, Yinglong</creatorcontrib><creatorcontrib>Cui, Peizhe</creatorcontrib><creatorcontrib>Zhu, Zhaoyou</creatorcontrib><creatorcontrib>Du, Deping</creatorcontrib><creatorcontrib>Wang, Kaiguang</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Qi, Jianguang</creatorcontrib><creatorcontrib>Xu, Wenhui</creatorcontrib><creatorcontrib>Zheng, Zhonghui</creatorcontrib><creatorcontrib>Zhong, Limei</creatorcontrib><creatorcontrib>Jia, Jianbo</creatorcontrib><title>Purification method and device for continuous distillation and separation of ibuprofen intermediate raw material</title><description>The present disclosure belongs to the technical field of chemical separation and purification, and in particular relates to a purification method and device for continuous distillation and separation of an ibuprofen intermediate raw material. The purification method comprises the following steps: carrying out a primary distillation on synthetic liquid to obtain a primary material and recovered 4-methyl-1-pentene, then carrying out a second-stage distillation on the primary material to obtain a second-stage material and a recovered crude toluene product; and carrying out a third-stage distillation on the second-stage material to obtain isobutyl benzene and a recovered crude n-butylbenzene product. Embodiment results show that the purification method provided by the present disclosure is high in product recovery rate and high in product purity, the purity of isobutyl benzene is up to 99.99 wt %, the recovery rate is up to 99.9 wt %, the impurity content is not higher than 50 ppm.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyj0KAjEQhuFtLES9w3gAwXUFrRXFUlDrZUwmOJDMhPzo9VXWA1h97wfPuInnmtixwcIqEKg81AKKBUtPNgROExiVwlK1ZrCcC3s_6C_LFDENVx3wvcakjgRYCqVAlrEQJHxB-ERi9NNm5NBnmv120syPh-v-tKCoPeWIhoRKf7u07Xa13Ky7Xdv9Y97mVUR4</recordid><startdate>20231121</startdate><enddate>20231121</enddate><creator>Wang, Yinglong</creator><creator>Cui, Peizhe</creator><creator>Zhu, Zhaoyou</creator><creator>Du, Deping</creator><creator>Wang, Kaiguang</creator><creator>Li, Xin</creator><creator>Qi, Jianguang</creator><creator>Xu, Wenhui</creator><creator>Zheng, Zhonghui</creator><creator>Zhong, Limei</creator><creator>Jia, Jianbo</creator><scope>EVB</scope></search><sort><creationdate>20231121</creationdate><title>Purification method and device for continuous distillation and separation of ibuprofen intermediate raw material</title><author>Wang, Yinglong ; Cui, Peizhe ; Zhu, Zhaoyou ; Du, Deping ; Wang, Kaiguang ; Li, Xin ; Qi, Jianguang ; Xu, Wenhui ; Zheng, Zhonghui ; Zhong, Limei ; Jia, Jianbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US11820743B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yinglong</creatorcontrib><creatorcontrib>Cui, Peizhe</creatorcontrib><creatorcontrib>Zhu, Zhaoyou</creatorcontrib><creatorcontrib>Du, Deping</creatorcontrib><creatorcontrib>Wang, Kaiguang</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Qi, Jianguang</creatorcontrib><creatorcontrib>Xu, Wenhui</creatorcontrib><creatorcontrib>Zheng, Zhonghui</creatorcontrib><creatorcontrib>Zhong, Limei</creatorcontrib><creatorcontrib>Jia, Jianbo</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Wang, Yinglong</au><au>Cui, Peizhe</au><au>Zhu, Zhaoyou</au><au>Du, Deping</au><au>Wang, Kaiguang</au><au>Li, Xin</au><au>Qi, Jianguang</au><au>Xu, Wenhui</au><au>Zheng, Zhonghui</au><au>Zhong, Limei</au><au>Jia, Jianbo</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Purification method and device for continuous distillation and separation of ibuprofen intermediate raw material</title><date>2023-11-21</date><risdate>2023</risdate><abstract>The present disclosure belongs to the technical field of chemical separation and purification, and in particular relates to a purification method and device for continuous distillation and separation of an ibuprofen intermediate raw material. The purification method comprises the following steps: carrying out a primary distillation on synthetic liquid to obtain a primary material and recovered 4-methyl-1-pentene, then carrying out a second-stage distillation on the primary material to obtain a second-stage material and a recovered crude toluene product; and carrying out a third-stage distillation on the second-stage material to obtain isobutyl benzene and a recovered crude n-butylbenzene product. Embodiment results show that the purification method provided by the present disclosure is high in product recovery rate and high in product purity, the purity of isobutyl benzene is up to 99.99 wt %, the recovery rate is up to 99.9 wt %, the impurity content is not higher than 50 ppm.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US11820743B1 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | Purification method and device for continuous distillation and separation of ibuprofen intermediate raw material |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T18%3A12%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Wang,%20Yinglong&rft.date=2023-11-21&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS11820743B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |