Method for producing optically active pyrrolidine compounds

The present invention provides a process for preparing a compound represented by formula (VII), which comprises reacting a compound represented by formula (VI) with a malonic acid derivative in the presence of a base and an asymmetric catalyst in a two layer solvent system of hydrophobic solvent and...

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Bibliographische Detailangaben
Hauptverfasser: Yamaguchi, Tetsuo, Yamagami, Takafumi, Teshima, Takao, Ando, Junki
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides a process for preparing a compound represented by formula (VII), which comprises reacting a compound represented by formula (VI) with a malonic acid derivative in the presence of a base and an asymmetric catalyst in a two layer solvent system of hydrophobic solvent and water,(wherein R2 and R3 each independently represents a protecting group for carboxyl group).