RNAi constructs for inhibiting ASGR1 expression and methods of use thereof
The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Cheng, Yuan Wu, Bin Yoon, Oh Kyu Ollmann, Michael Li, Yang Homann, Oliver Zhang, Jun Murray, Justin K Netirojjanakul, Chawita Miranda, Leslie P Allen, John Gordon |
| description | The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US11732266B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US11732266B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US11732266B23</originalsourceid><addsrcrecordid>eNqNyjsOwjAMANAsDAi4gzkAQ1KpzAXxEQNDC3MVWodYgjiKXYnjs3AApre8ubm014Zg4CRapkEFAhegFOlBSukJTXdqLeAnFxQhTuDTCG_UyKMAB5gEQSMW5LA0s-BfgqufC7M-Hm778wYz9yjZD5hQ-3tn7bZyrq53rvrnfAHNhTSP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>RNAi constructs for inhibiting ASGR1 expression and methods of use thereof</title><source>esp@cenet</source><creator>Cheng, Yuan ; Wu, Bin ; Yoon, Oh Kyu ; Ollmann, Michael ; Li, Yang ; Homann, Oliver ; Zhang, Jun ; Murray, Justin K ; Netirojjanakul, Chawita ; Miranda, Leslie P ; Allen, John Gordon</creator><creatorcontrib>Cheng, Yuan ; Wu, Bin ; Yoon, Oh Kyu ; Ollmann, Michael ; Li, Yang ; Homann, Oliver ; Zhang, Jun ; Murray, Justin K ; Netirojjanakul, Chawita ; Miranda, Leslie P ; Allen, John Gordon</creatorcontrib><description>The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230822&DB=EPODOC&CC=US&NR=11732266B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230822&DB=EPODOC&CC=US&NR=11732266B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Cheng, Yuan</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Yoon, Oh Kyu</creatorcontrib><creatorcontrib>Ollmann, Michael</creatorcontrib><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Homann, Oliver</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Murray, Justin K</creatorcontrib><creatorcontrib>Netirojjanakul, Chawita</creatorcontrib><creatorcontrib>Miranda, Leslie P</creatorcontrib><creatorcontrib>Allen, John Gordon</creatorcontrib><title>RNAi constructs for inhibiting ASGR1 expression and methods of use thereof</title><description>The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjsOwjAMANAsDAi4gzkAQ1KpzAXxEQNDC3MVWodYgjiKXYnjs3AApre8ubm014Zg4CRapkEFAhegFOlBSukJTXdqLeAnFxQhTuDTCG_UyKMAB5gEQSMW5LA0s-BfgqufC7M-Hm778wYz9yjZD5hQ-3tn7bZyrq53rvrnfAHNhTSP</recordid><startdate>20230822</startdate><enddate>20230822</enddate><creator>Cheng, Yuan</creator><creator>Wu, Bin</creator><creator>Yoon, Oh Kyu</creator><creator>Ollmann, Michael</creator><creator>Li, Yang</creator><creator>Homann, Oliver</creator><creator>Zhang, Jun</creator><creator>Murray, Justin K</creator><creator>Netirojjanakul, Chawita</creator><creator>Miranda, Leslie P</creator><creator>Allen, John Gordon</creator><scope>EVB</scope></search><sort><creationdate>20230822</creationdate><title>RNAi constructs for inhibiting ASGR1 expression and methods of use thereof</title><author>Cheng, Yuan ; Wu, Bin ; Yoon, Oh Kyu ; Ollmann, Michael ; Li, Yang ; Homann, Oliver ; Zhang, Jun ; Murray, Justin K ; Netirojjanakul, Chawita ; Miranda, Leslie P ; Allen, John Gordon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US11732266B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Yuan</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Yoon, Oh Kyu</creatorcontrib><creatorcontrib>Ollmann, Michael</creatorcontrib><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Homann, Oliver</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Murray, Justin K</creatorcontrib><creatorcontrib>Netirojjanakul, Chawita</creatorcontrib><creatorcontrib>Miranda, Leslie P</creatorcontrib><creatorcontrib>Allen, John Gordon</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Cheng, Yuan</au><au>Wu, Bin</au><au>Yoon, Oh Kyu</au><au>Ollmann, Michael</au><au>Li, Yang</au><au>Homann, Oliver</au><au>Zhang, Jun</au><au>Murray, Justin K</au><au>Netirojjanakul, Chawita</au><au>Miranda, Leslie P</au><au>Allen, John Gordon</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>RNAi constructs for inhibiting ASGR1 expression and methods of use thereof</title><date>2023-08-22</date><risdate>2023</risdate><abstract>The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US11732266B2 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | RNAi constructs for inhibiting ASGR1 expression and methods of use thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T21%3A31%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Cheng,%20Yuan&rft.date=2023-08-22&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS11732266B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |