Azalactam compounds as HPK1 inhibitors

Azalactam compounds as HPK1 inhibitors

This invention relates to compounds of general Formula Iand pharmaceutically acceptable salts thereof, in which R1, R2, R3a, R3b, and R4 are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Ru, Zhou, Dahui, Gallego, Rebecca Anne, Del Bel, Matthew L, He, Mingying, Barber, Joyann, Tuttle, Jamison Bryce, Jalaie, Mehran, Nair, Sajiv Krishnan, Schmitt, Anne-Marie Dechert, Kania, Robert Steven, Cho-Schultz, Sujin, McTigue, Michele Ann
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:This invention relates to compounds of general Formula Iand pharmaceutically acceptable salts thereof, in which R1, R2, R3a, R3b, and R4 are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.