Masked activatable interferon constructs
Provided herein are activatable cytokine constructs that include: (a) a first monomer construct comprising a first peptide mask (PM1), a third cleavable moiety (CM3), a first mature cytokine protein (CP1), a first cleavable moiety (CM1), and a first dimerization domain (DD1), wherein the CM1 is posi...
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| creator | Daniel, Dylan L Bogdanoff, Walter A Assi, Hikmat Haizar Wang, Hsin Paidhungat, Madan M Lapuyade, Nicole G Cai, Na Berezhnoy, Alexey Yevgenyevich Le Scolan, Erwan Mitra, Sayantan |
| description | Provided herein are activatable cytokine constructs that include: (a) a first monomer construct comprising a first peptide mask (PM1), a third cleavable moiety (CM3), a first mature cytokine protein (CP1), a first cleavable moiety (CM1), and a first dimerization domain (DD1), wherein the CM1 is positioned between the CP1 and the DD1, and the CM3 is positioned between the PM1 and CP1; and (b) a second monomer construct comprising a second mature cytokine protein (CP2), a second cleavable moiety (CM2), and a second dimerization domain (DD2), where the CM2 is positioned between the CP2 and the DD2, where: the DD1 and the DD2 bind each other; and where the ACC is characterized by a reduction in at least one activity of the CP1 and/or CP2 as compared to a control level of the at least one activity of the CP1 and/or CP2. |
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and (b) a second monomer construct comprising a second mature cytokine protein (CP2), a second cleavable moiety (CM2), and a second dimerization domain (DD2), where the CM2 is positioned between the CP2 and the DD2, where: the DD1 and the DD2 bind each other; and where the ACC is characterized by a reduction in at least one activity of the CP1 and/or CP2 as compared to a control level of the at least one activity of the CP1 and/or CP2.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDwTSzOTk1RSEwuySxLLElMyklVyMwrSS1KSy3Kz1NIzs8rLikqTS4p5mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8aHBhoZmZuZmFuZORsbEqAEADQgpIA</recordid><startdate>20230606</startdate><enddate>20230606</enddate><creator>Daniel, Dylan L</creator><creator>Bogdanoff, Walter A</creator><creator>Assi, Hikmat Haizar</creator><creator>Wang, Hsin</creator><creator>Paidhungat, Madan M</creator><creator>Lapuyade, Nicole G</creator><creator>Cai, Na</creator><creator>Berezhnoy, Alexey Yevgenyevich</creator><creator>Le Scolan, Erwan</creator><creator>Mitra, Sayantan</creator><scope>EVB</scope></search><sort><creationdate>20230606</creationdate><title>Masked activatable interferon constructs</title><author>Daniel, Dylan L ; Bogdanoff, Walter A ; Assi, Hikmat Haizar ; Wang, Hsin ; Paidhungat, Madan M ; Lapuyade, Nicole G ; Cai, Na ; Berezhnoy, Alexey Yevgenyevich ; Le Scolan, Erwan ; Mitra, Sayantan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US11667687B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>Daniel, Dylan L</creatorcontrib><creatorcontrib>Bogdanoff, Walter A</creatorcontrib><creatorcontrib>Assi, Hikmat Haizar</creatorcontrib><creatorcontrib>Wang, Hsin</creatorcontrib><creatorcontrib>Paidhungat, Madan M</creatorcontrib><creatorcontrib>Lapuyade, Nicole G</creatorcontrib><creatorcontrib>Cai, Na</creatorcontrib><creatorcontrib>Berezhnoy, Alexey Yevgenyevich</creatorcontrib><creatorcontrib>Le Scolan, Erwan</creatorcontrib><creatorcontrib>Mitra, Sayantan</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Daniel, Dylan L</au><au>Bogdanoff, Walter A</au><au>Assi, Hikmat Haizar</au><au>Wang, Hsin</au><au>Paidhungat, Madan M</au><au>Lapuyade, Nicole G</au><au>Cai, Na</au><au>Berezhnoy, Alexey Yevgenyevich</au><au>Le Scolan, Erwan</au><au>Mitra, Sayantan</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Masked activatable interferon constructs</title><date>2023-06-06</date><risdate>2023</risdate><abstract>Provided herein are activatable cytokine constructs that include: (a) a first monomer construct comprising a first peptide mask (PM1), a third cleavable moiety (CM3), a first mature cytokine protein (CP1), a first cleavable moiety (CM1), and a first dimerization domain (DD1), wherein the CM1 is positioned between the CP1 and the DD1, and the CM3 is positioned between the PM1 and CP1; and (b) a second monomer construct comprising a second mature cytokine protein (CP2), a second cleavable moiety (CM2), and a second dimerization domain (DD2), where the CM2 is positioned between the CP2 and the DD2, where: the DD1 and the DD2 bind each other; and where the ACC is characterized by a reduction in at least one activity of the CP1 and/or CP2 as compared to a control level of the at least one activity of the CP1 and/or CP2.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
| title | Masked activatable interferon constructs |
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