Systems and methods for performing response based cache redirection

The present disclosure relates to methods and systems for performing response based cache redirection to a cache proxy. A device intermediary to a plurality of clients and a plurality of servers and in communication with a plurality of cache proxies, receives a request for content from a client. The request is for content from a server of the plurality of servers. The device forwards the request to the server. The device identifies a cache redirection policy that specifies an amount of bytes of a response to buffer to calculate a signature of the content of the response. The device computes the signature of the content of the response based on the amount of bytes of the response received from the server and buffered by the device. The device selects a cache proxy based on the computed signature and forwards the request of the client to the selected cache proxy.