Prevention of organizational data leakage across platforms based on device status

Technologies are provided for prevention of organizational data leakage across platforms based on device status. A device management service may include status information for a client device and/or a connection in a token provided to the client device and update the status in response to changes. An applicable data protection policy may be determined based on the detected status and optionally based on data being accessed. An instruction may be transmitted to a client application executed on the client device based on the applicable data protection policy thereby enforcing the data protection policy at the server. The instruction may cause a script executed at the client application to disable one or more user interface controls associated with functionality such as downloading, synchronizing, printing, etc. of the organizational data to prevent leakage of organizational data.