Cytotoxic and anti-mitotic compounds, and methods of using the same
Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) i...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Babcook, John Mandel, Alexander Laurence Winters, Geoffrey C Rich, James R Hedberg, Bradley John Hsieh, Tom Han Hsiao Bourque, Elyse Marie Josée |
| description | Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US11617777B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US11617777B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US11617777B23</originalsourceid><addsrcrecordid>eNrjZHB2rizJL8mvyExWSMxLAeKSTN3cTKAQUCA5P7cgvzQvpVgHLJebWpKRn1KskJ-mUFqcmZeuUJKRqlCcmJvKw8CalphTnMoLpbkZFN1cQ5w9dFML8uNTiwsSk1PzUkviQ4MNDc0MzYHAyciYGDUAauIyYA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Cytotoxic and anti-mitotic compounds, and methods of using the same</title><source>esp@cenet</source><creator>Babcook, John ; Mandel, Alexander Laurence ; Winters, Geoffrey C ; Rich, James R ; Hedberg, Bradley John ; Hsieh, Tom Han Hsiao ; Bourque, Elyse Marie Josée</creator><creatorcontrib>Babcook, John ; Mandel, Alexander Laurence ; Winters, Geoffrey C ; Rich, James R ; Hedberg, Bradley John ; Hsieh, Tom Han Hsiao ; Bourque, Elyse Marie Josée</creatorcontrib><description>Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230404&DB=EPODOC&CC=US&NR=11617777B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230404&DB=EPODOC&CC=US&NR=11617777B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Babcook, John</creatorcontrib><creatorcontrib>Mandel, Alexander Laurence</creatorcontrib><creatorcontrib>Winters, Geoffrey C</creatorcontrib><creatorcontrib>Rich, James R</creatorcontrib><creatorcontrib>Hedberg, Bradley John</creatorcontrib><creatorcontrib>Hsieh, Tom Han Hsiao</creatorcontrib><creatorcontrib>Bourque, Elyse Marie Josée</creatorcontrib><title>Cytotoxic and anti-mitotic compounds, and methods of using the same</title><description>Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHB2rizJL8mvyExWSMxLAeKSTN3cTKAQUCA5P7cgvzQvpVgHLJebWpKRn1KskJ-mUFqcmZeuUJKRqlCcmJvKw8CalphTnMoLpbkZFN1cQ5w9dFML8uNTiwsSk1PzUkviQ4MNDc0MzYHAyciYGDUAauIyYA</recordid><startdate>20230404</startdate><enddate>20230404</enddate><creator>Babcook, John</creator><creator>Mandel, Alexander Laurence</creator><creator>Winters, Geoffrey C</creator><creator>Rich, James R</creator><creator>Hedberg, Bradley John</creator><creator>Hsieh, Tom Han Hsiao</creator><creator>Bourque, Elyse Marie Josée</creator><scope>EVB</scope></search><sort><creationdate>20230404</creationdate><title>Cytotoxic and anti-mitotic compounds, and methods of using the same</title><author>Babcook, John ; Mandel, Alexander Laurence ; Winters, Geoffrey C ; Rich, James R ; Hedberg, Bradley John ; Hsieh, Tom Han Hsiao ; Bourque, Elyse Marie Josée</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US11617777B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Babcook, John</creatorcontrib><creatorcontrib>Mandel, Alexander Laurence</creatorcontrib><creatorcontrib>Winters, Geoffrey C</creatorcontrib><creatorcontrib>Rich, James R</creatorcontrib><creatorcontrib>Hedberg, Bradley John</creatorcontrib><creatorcontrib>Hsieh, Tom Han Hsiao</creatorcontrib><creatorcontrib>Bourque, Elyse Marie Josée</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Babcook, John</au><au>Mandel, Alexander Laurence</au><au>Winters, Geoffrey C</au><au>Rich, James R</au><au>Hedberg, Bradley John</au><au>Hsieh, Tom Han Hsiao</au><au>Bourque, Elyse Marie Josée</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Cytotoxic and anti-mitotic compounds, and methods of using the same</title><date>2023-04-04</date><risdate>2023</risdate><abstract>Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US11617777B2 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T07%3A36%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Babcook,%20John&rft.date=2023-04-04&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS11617777B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |