Methods for application deployment across multiple computing domains and devices thereof

Technology related to application deployment across network devices including smart network interface cards. In one example, a method includes distributing an application across a plurality of locally connected computing subdomains. The subdomains can include a mixture of general and special purpose computing subdomains, such as for example, a main computer and an associated smart network interface devices or systems, such as for example a smart network interface card (NIC). The subdomains can each run hypervisors that are bridged to allow a single virtual machine to operate across the subdomains. The application can include multiple portions. For example, an application can be split by different functionalities. The application portions can be tagged to indicate which subdomain they are to be executed within. If the chosen subdomain has available the requisite resources, the application can be detached and distributed to the chosen subdomain.