Inhalable liposomal sustained release composition for use in treating pulmonary diseases

Inhalable liposomal sustained release composition for use in treating pulmonary diseases

Provided is a liposomal sustained-release composition for use in treatment of pulmonary disease. The liposomal sustained release composition comprises a liposome that includes a polyethylene glycol (PEG)-modified lipid and encapsulates a tyrosine kinase inhibitor. Tyrosine kinase inhibitor is stably...

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Hauptverfasser: Tseng, Yu-Cheng, Fang, Jonathan, Yu, Wan-Ni, Hong, Keelung, Tang, Jo-Hsin, Cheng, Ting-Yu
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator Tseng, Yu-Cheng
Fang, Jonathan
Yu, Wan-Ni
Hong, Keelung
Tang, Jo-Hsin
Cheng, Ting-Yu
description Provided is a liposomal sustained-release composition for use in treatment of pulmonary disease. The liposomal sustained release composition comprises a liposome that includes a polyethylene glycol (PEG)-modified lipid and encapsulates a tyrosine kinase inhibitor. Tyrosine kinase inhibitor is stably entrapped in the liposome, and the resulting liposomal drug formulation can be aerosolized or nebulized for administration via inhalation. This aerosolized liposomal drug formulation yields consistent pharmacokinetic and pharmacodynamic profiles while achieving desired efficacy and safety.
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HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Inhalable liposomal sustained release composition for use in treating pulmonary diseases
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