Cholix-derived carriers for oral delivery of heterologous payload

The present disclosure provides delivery constructs comprising a carrier coupled to a heterologous payload, wherein coupling of the carrier to the payload can result in transportation of the payload (e.g., a therapeutic payload) into and/or across intact polarized epithelial cells (e.g., epithelial...

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Hauptverfasser: Olson, Charles, Mahmood, Tahir, Mrsny, Randall J, Feng, Weijun, Postlethwaite, Sally, Hunter, Thomas Carl
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creator Olson, Charles
Mahmood, Tahir
Mrsny, Randall J
Feng, Weijun
Postlethwaite, Sally
Hunter, Thomas Carl
description The present disclosure provides delivery constructs comprising a carrier coupled to a heterologous payload, wherein coupling of the carrier to the payload can result in transportation of the payload (e.g., a therapeutic payload) into and/or across intact polarized epithelial cells (e.g., epithelial cells of the gut of a mammal). The delivery construct can be part of a pharmaceutical composition that can be orally administered to a subject to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases or autoimmune diseases.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Cholix-derived carriers for oral delivery of heterologous payload
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