Heterodimeric immunoglobulin constructs and preparation methods thereof
The present invention provides a method for production of stable and highly specific heterodimeric immunoglobulin constructs, e.g., bispecific antibodies, retaining desirable properties of native IgG and lacking undesirable heavy chain-light chain mispairing, that can simultaneously bind two target...
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| creator | Yang, Dongge Kim, Maengsup Yang, Yaping Liu, Jiawang Song, Nanmeng |
| description | The present invention provides a method for production of stable and highly specific heterodimeric immunoglobulin constructs, e.g., bispecific antibodies, retaining desirable properties of native IgG and lacking undesirable heavy chain-light chain mispairing, that can simultaneously bind two target molecules and are more potent in the treatment of complex diseases. |
| format | Patent |
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HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221115&DB=EPODOC&CC=US&NR=11498977B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221115&DB=EPODOC&CC=US&NR=11498977B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Yang, Dongge</creatorcontrib><creatorcontrib>Kim, Maengsup</creatorcontrib><creatorcontrib>Yang, Yaping</creatorcontrib><creatorcontrib>Liu, Jiawang</creatorcontrib><creatorcontrib>Song, Nanmeng</creatorcontrib><title>Heterodimeric immunoglobulin constructs and preparation methods thereof</title><description>The present invention provides a method for production of stable and highly specific heterodimeric immunoglobulin constructs, e.g., bispecific antibodies, retaining desirable properties of native IgG and lacking undesirable heavy chain-light chain mispairing, that can simultaneously bind two target molecules and are more potent in the treatment of complex diseases.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEOwjAMBdAsDAi4gzkAQwGpdAUB3YG5CukvjZTYUeLcn4UDML3lLc29hyLL6COyd-RjrCyfIO8aPJMTLpqr00KWR0oZyWarXpgidJaxkM7IkGltFpMNBZufK7O9XZ-XfockA0qyDgwdXo-mOXanrm3P-8M_5wsWZjWE</recordid><startdate>20221115</startdate><enddate>20221115</enddate><creator>Yang, Dongge</creator><creator>Kim, Maengsup</creator><creator>Yang, Yaping</creator><creator>Liu, Jiawang</creator><creator>Song, Nanmeng</creator><scope>EVB</scope></search><sort><creationdate>20221115</creationdate><title>Heterodimeric immunoglobulin constructs and preparation methods thereof</title><author>Yang, Dongge ; 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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Heterodimeric immunoglobulin constructs and preparation methods thereof |
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