Necrosis inhibitors
The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and meth...
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| creator | Zhang, Zhiyuan Ruan, Hanying Wang, Xiaodong Ren, Yan Su, Yaning |
| description | The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition. |
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The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; GYROSCOPIC INSTRUMENTS ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEASURING ; MEASURING DISTANCES, LEVELS OR BEARINGS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NAVIGATION ; ORGANIC CHEMISTRY ; PHOTOGRAMMETRY OR VIDEOGRAMMETRY ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SURVEYING ; TESTING</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221025&DB=EPODOC&CC=US&NR=11478438B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221025&DB=EPODOC&CC=US&NR=11478438B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Zhang, Zhiyuan</creatorcontrib><creatorcontrib>Ruan, Hanying</creatorcontrib><creatorcontrib>Wang, Xiaodong</creatorcontrib><creatorcontrib>Ren, Yan</creatorcontrib><creatorcontrib>Su, Yaning</creatorcontrib><title>Necrosis inhibitors</title><description>The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. 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The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY GYROSCOPIC INSTRUMENTS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEASURING MEASURING DISTANCES, LEVELS OR BEARINGS MEDICAL OR VETERINARY SCIENCE METALLURGY NAVIGATION ORGANIC CHEMISTRY PHOTOGRAMMETRY OR VIDEOGRAMMETRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SURVEYING TESTING |
| title | Necrosis inhibitors |
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