Process for the monotopic preparation of intermediate organo-iodinated compounds for the synthesis of ioversol
A process for preparing an organo-iodinated compound, comprising the following steps:a) acylating 2,4,6-triiodo-5-aminoisophthalic acid of formula (A) below:to obtain an intermediate compound Ya;b) chlorinating the intermediate compound Ya to obtain an organo-iodinated intermediate compound Yb;c) am...
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| creator | Stéphan, Pellinghelli Petta, Myriam |
| description | A process for preparing an organo-iodinated compound, comprising the following steps:a) acylating 2,4,6-triiodo-5-aminoisophthalic acid of formula (A) below:to obtain an intermediate compound Ya;b) chlorinating the intermediate compound Ya to obtain an organo-iodinated intermediate compound Yb;c) amidating the organo-iodinated intermediate compound Yb to obtain an intermediate compound Yc; andd) deprotecting the intermediate compound Yc, the steps a), b), c) and d) being carried out without isolation of at least one intermediate compound chosen from Ya and Yc. |
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andd) deprotecting the intermediate compound Yc, the steps a), b), c) and d) being carried out without isolation of at least one intermediate compound chosen from Ya and Yc.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221018&DB=EPODOC&CC=US&NR=11472767B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221018&DB=EPODOC&CC=US&NR=11472767B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Stéphan, Pellinghelli</creatorcontrib><creatorcontrib>Petta, Myriam</creatorcontrib><title>Process for the monotopic preparation of intermediate organo-iodinated compounds for the synthesis of ioversol</title><description>A process for preparing an organo-iodinated compound, comprising the following steps:a) acylating 2,4,6-triiodo-5-aminoisophthalic acid of formula (A) below:to obtain an intermediate compound Ya;b) chlorinating the intermediate compound Ya to obtain an organo-iodinated intermediate compound Yb;c) amidating the organo-iodinated intermediate compound Yb to obtain an intermediate compound Yc; 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| title | Process for the monotopic preparation of intermediate organo-iodinated compounds for the synthesis of ioversol |
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