Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors

The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of t...

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Hauptverfasser: Hajare, Anil Kashiram, Palle, Venkata P, Gore, Balasaheb Arjun, Sindkhedkar, Milind Dattatraya, Nair, Prathap Sreedharan, Sethi, Sachin, Kamboj, Rajender Kumar, Lagad, Dipak Raychand, Gudade, Ganesh Bhausaheb, Kulkarni, Chaitanya Prabhakar, Pawar, Chetan Sanjay, Tryambake, Mahadeo Bhaskar, Kulkarni, Sanjeev Anant
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creator Hajare, Anil Kashiram
Palle, Venkata P
Gore, Balasaheb Arjun
Sindkhedkar, Milind Dattatraya
Nair, Prathap Sreedharan
Sethi, Sachin
Kamboj, Rajender Kumar
Lagad, Dipak Raychand
Gudade, Ganesh Bhausaheb
Kulkarni, Chaitanya Prabhakar
Pawar, Chetan Sanjay
Tryambake, Mahadeo Bhaskar
Kulkarni, Sanjeev Anant
description The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors
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