LTBP complex-specific inhibitors of TGFβ and uses thereof
Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering f...
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| creator | Wawersik, Stefan Stein, Caitlin Fogel, Adam Datta, Abhishek McCreary, Julia Schurpf, Thomas Salotto, Matthew Littlefield, Christopher Streich, Jr., Frederick Jackson, Justin W Coricor, George |
| description | Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided. |
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The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220621&DB=EPODOC&CC=US&NR=11365245B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220621&DB=EPODOC&CC=US&NR=11365245B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Wawersik, Stefan</creatorcontrib><creatorcontrib>Stein, Caitlin</creatorcontrib><creatorcontrib>Fogel, Adam</creatorcontrib><creatorcontrib>Datta, Abhishek</creatorcontrib><creatorcontrib>McCreary, Julia</creatorcontrib><creatorcontrib>Schurpf, Thomas</creatorcontrib><creatorcontrib>Salotto, Matthew</creatorcontrib><creatorcontrib>Littlefield, Christopher</creatorcontrib><creatorcontrib>Streich, Jr., Frederick</creatorcontrib><creatorcontrib>Jackson, Justin W</creatorcontrib><creatorcontrib>Coricor, George</creatorcontrib><title>LTBP complex-specific inhibitors of TGFβ and uses thereof</title><description>Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. 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| title | LTBP complex-specific inhibitors of TGFβ and uses thereof |
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