Heteroaryl piperidine ether allosteric modulators of the M4 muscarinic acetylcholine receptor

The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychia...

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Hauptverfasser: Lo, Michael Man-Chu, Ferguson, Ronald, Gao, Xiaolei, Harrison, Scott, Bao, Jianming, Mazzola, Jr., Robert D, Shubert, Jeffrey W, Knowles, Sandra L
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creator Lo, Michael Man-Chu
Ferguson, Ronald
Gao, Xiaolei
Harrison, Scott
Bao, Jianming
Mazzola, Jr., Robert D
Shubert, Jeffrey W
Knowles, Sandra L
description The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Heteroaryl piperidine ether allosteric modulators of the M4 muscarinic acetylcholine receptor
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