Substituted piperazines as KRAS G12C inhibitors
Provided herein are KRAS G12C inhibitors, such ascomposition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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| creator | Amegadzie, Albert Low, Jonathan D Wurz, Ryan Paul Lopez, Patricia Wang, Hui-Ling Xue, Qiufen Nguyen, Thomas T Chu-Moyer, Margaret Walton, Mary Chen, Jian Ma, Vu Van Goodman, Clifford Booker, Shon Reed, Anthony B Cee, Victor J Liu, Longbin Shin, Youngsook Minatti, Ana Elena Lanman, Brian Alan Chen, Ning Pickrell, Alexander J Siegmund, Aaron C Allen, John Gordon Allen, Jennifer Rebecca Nishimura, Nobuko Yang, Kevin C Tamayo, Nuria A |
| description | Provided herein are KRAS G12C inhibitors, such ascomposition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers. |
| format | Patent |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Substituted piperazines as KRAS G12C inhibitors |
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