Neutralizing anti-influenza A antibodies and uses thereof

The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus. In one embodiment, an antibody or binding fragment according to the inve...

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Hauptverfasser: Palmer-Hill, Frances, Lanzavecchia, Antonio, McAuliffe, Josephine Mary, Yuan, Andy, DeMarco, Anna, Kallewaard-LeLay, Nicole, Benjamin, Ebony, Guarino, Barbara, Wachter, Leslie, Zhu, Qing, Corti, Davide
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creator Palmer-Hill, Frances
Lanzavecchia, Antonio
McAuliffe, Josephine Mary
Yuan, Andy
DeMarco, Anna
Kallewaard-LeLay, Nicole
Benjamin, Ebony
Guarino, Barbara
Wachter, Leslie
Zhu, Qing
Corti, Davide
description The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus. In one embodiment, an antibody or binding fragment according to the invention is capable of binding to and/or neutralizing one or more influenza A virus group 1 subtypes selected from H1, H2, H5, H6, H8, H9, H11, H12, H13, H16 and H17 and variants thereof and one or more influenza A virus group 2 subtype selected from H3, H4, H7, H1, 0, H14 and H15 and variants thereof.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPIRITS
TESTING
VINEGAR
WINE
title Neutralizing anti-influenza A antibodies and uses thereof
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