Site-specific conjugation of linker drugs to antibodies and resulting ADCS

The present invention relates to antibody-drug conjugates (ADCs) wherein a linker drug is site-specifically conjugated to an antibody through an engineered cysteine, and their use as a medicament, notably for the treatment of human solid tumours and haematological malignancies, in particular breast...

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Bibliographische Detailangaben
Hauptverfasser: Coumans, Rudy Gerardus Elisabeth, Ariaans, Gerardus Joseph Andreas
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to antibody-drug conjugates (ADCs) wherein a linker drug is site-specifically conjugated to an antibody through an engineered cysteine, and their use as a medicament, notably for the treatment of human solid tumours and haematological malignancies, in particular breast cancer, gastric cancer, colorectal cancer, urothelial cancer, ovarian cancer, uterine cancer, lung cancer, mesothelioma, liver cancer, pancreatic cancer, prostate cancer, and leukaemia.