Heteroaromatic compounds useful for the treatment of proliferative diseases
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or p...
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| creator | Siddiqui, M. Arshad Schmidt, Darby Miller, Tom Marineau, Jason J Leblanc, Melissa Gray, Nathanael Sprott, Kevin Bradley, Michael Roy, Stephanie Ciblat, Stephane Leger, Serge Deroy, Patrick Zhang, Tinghu Winter, Dana K Moore, Joel Kabro, Anzhelika |
| description | The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. |
| format | Patent |
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Arshad ; Schmidt, Darby ; Miller, Tom ; Marineau, Jason J ; Leblanc, Melissa ; Gray, Nathanael ; Sprott, Kevin ; Bradley, Michael ; Roy, Stephanie ; Ciblat, Stephane ; Leger, Serge ; Deroy, Patrick ; Zhang, Tinghu ; Winter, Dana K ; Moore, Joel ; Kabro, Anzhelika</creator><creatorcontrib>Siddiqui, M. Arshad ; Schmidt, Darby ; Miller, Tom ; Marineau, Jason J ; Leblanc, Melissa ; Gray, Nathanael ; Sprott, Kevin ; Bradley, Michael ; Roy, Stephanie ; Ciblat, Stephane ; Leger, Serge ; Deroy, Patrick ; Zhang, Tinghu ; Winter, Dana K ; Moore, Joel ; Kabro, Anzhelika</creatorcontrib><description>The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210622&DB=EPODOC&CC=US&NR=11040957B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210622&DB=EPODOC&CC=US&NR=11040957B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Siddiqui, M. Arshad</creatorcontrib><creatorcontrib>Schmidt, Darby</creatorcontrib><creatorcontrib>Miller, Tom</creatorcontrib><creatorcontrib>Marineau, Jason J</creatorcontrib><creatorcontrib>Leblanc, Melissa</creatorcontrib><creatorcontrib>Gray, Nathanael</creatorcontrib><creatorcontrib>Sprott, Kevin</creatorcontrib><creatorcontrib>Bradley, Michael</creatorcontrib><creatorcontrib>Roy, Stephanie</creatorcontrib><creatorcontrib>Ciblat, Stephane</creatorcontrib><creatorcontrib>Leger, Serge</creatorcontrib><creatorcontrib>Deroy, Patrick</creatorcontrib><creatorcontrib>Zhang, Tinghu</creatorcontrib><creatorcontrib>Winter, Dana K</creatorcontrib><creatorcontrib>Moore, Joel</creatorcontrib><creatorcontrib>Kabro, Anzhelika</creatorcontrib><title>Heteroaromatic compounds useful for the treatment of proliferative diseases</title><description>The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. 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Arshad</creatorcontrib><creatorcontrib>Schmidt, Darby</creatorcontrib><creatorcontrib>Miller, Tom</creatorcontrib><creatorcontrib>Marineau, Jason J</creatorcontrib><creatorcontrib>Leblanc, Melissa</creatorcontrib><creatorcontrib>Gray, Nathanael</creatorcontrib><creatorcontrib>Sprott, Kevin</creatorcontrib><creatorcontrib>Bradley, Michael</creatorcontrib><creatorcontrib>Roy, Stephanie</creatorcontrib><creatorcontrib>Ciblat, Stephane</creatorcontrib><creatorcontrib>Leger, Serge</creatorcontrib><creatorcontrib>Deroy, Patrick</creatorcontrib><creatorcontrib>Zhang, Tinghu</creatorcontrib><creatorcontrib>Winter, Dana K</creatorcontrib><creatorcontrib>Moore, Joel</creatorcontrib><creatorcontrib>Kabro, Anzhelika</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Siddiqui, M. Arshad</au><au>Schmidt, Darby</au><au>Miller, Tom</au><au>Marineau, Jason J</au><au>Leblanc, Melissa</au><au>Gray, Nathanael</au><au>Sprott, Kevin</au><au>Bradley, Michael</au><au>Roy, Stephanie</au><au>Ciblat, Stephane</au><au>Leger, Serge</au><au>Deroy, Patrick</au><au>Zhang, Tinghu</au><au>Winter, Dana K</au><au>Moore, Joel</au><au>Kabro, Anzhelika</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Heteroaromatic compounds useful for the treatment of proliferative diseases</title><date>2021-06-22</date><risdate>2021</risdate><abstract>The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Heteroaromatic compounds useful for the treatment of proliferative diseases |
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