Compositions and methods for treating insomnia

Compositions and methods for treating insomnia

In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zaima, Yasuhiro, Pastino, Gina, Akimoto, Yurie, Suzuki, Nobuya, Moline, Margaret, Yoshida, Nobuo
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Zaima, Yasuhiro
Pastino, Gina
Akimoto, Yurie
Suzuki, Nobuya
Moline, Margaret
Yoshida, Nobuo
description In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US11026944B2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US11026944B2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US11026944B23</originalsourceid><addsrcrecordid>eNrjZNBzzs8tyC_OLMnMzytWSMxLUchNLcnITylWSMsvUigpSk0sycxLV8jMK87PzctM5GFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8aHBhoYGRmaWJiZORsbEqAEAKG8rEA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Compositions and methods for treating insomnia</title><source>esp@cenet</source><creator>Zaima, Yasuhiro ; Pastino, Gina ; Akimoto, Yurie ; Suzuki, Nobuya ; Moline, Margaret ; Yoshida, Nobuo</creator><creatorcontrib>Zaima, Yasuhiro ; Pastino, Gina ; Akimoto, Yurie ; Suzuki, Nobuya ; Moline, Margaret ; Yoshida, Nobuo</creatorcontrib><description>In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20210608&amp;DB=EPODOC&amp;CC=US&amp;NR=11026944B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20210608&amp;DB=EPODOC&amp;CC=US&amp;NR=11026944B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Zaima, Yasuhiro</creatorcontrib><creatorcontrib>Pastino, Gina</creatorcontrib><creatorcontrib>Akimoto, Yurie</creatorcontrib><creatorcontrib>Suzuki, Nobuya</creatorcontrib><creatorcontrib>Moline, Margaret</creatorcontrib><creatorcontrib>Yoshida, Nobuo</creatorcontrib><title>Compositions and methods for treating insomnia</title><description>In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBzzs8tyC_OLMnMzytWSMxLUchNLcnITylWSMsvUigpSk0sycxLV8jMK87PzctM5GFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8aHBhoYGRmaWJiZORsbEqAEAKG8rEA</recordid><startdate>20210608</startdate><enddate>20210608</enddate><creator>Zaima, Yasuhiro</creator><creator>Pastino, Gina</creator><creator>Akimoto, Yurie</creator><creator>Suzuki, Nobuya</creator><creator>Moline, Margaret</creator><creator>Yoshida, Nobuo</creator><scope>EVB</scope></search><sort><creationdate>20210608</creationdate><title>Compositions and methods for treating insomnia</title><author>Zaima, Yasuhiro ; Pastino, Gina ; Akimoto, Yurie ; Suzuki, Nobuya ; Moline, Margaret ; Yoshida, Nobuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US11026944B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2021</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Zaima, Yasuhiro</creatorcontrib><creatorcontrib>Pastino, Gina</creatorcontrib><creatorcontrib>Akimoto, Yurie</creatorcontrib><creatorcontrib>Suzuki, Nobuya</creatorcontrib><creatorcontrib>Moline, Margaret</creatorcontrib><creatorcontrib>Yoshida, Nobuo</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Zaima, Yasuhiro</au><au>Pastino, Gina</au><au>Akimoto, Yurie</au><au>Suzuki, Nobuya</au><au>Moline, Margaret</au><au>Yoshida, Nobuo</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compositions and methods for treating insomnia</title><date>2021-06-08</date><risdate>2021</risdate><abstract>In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_US11026944B2
source esp@cenet
subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Compositions and methods for treating insomnia
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T17%3A07%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Zaima,%20Yasuhiro&rft.date=2021-06-08&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS11026944B2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true