Lyophilized pharmaceutical compositions for vaginal delivery

Disclosed herein is a solid lyophilized vaginal dosage form that can have an effective amount of at least one active ingredient, a crystalline structure forming agent in an amount of about 5 wt. % to about 40 wt. %, based on the total weight of the lyophilized dosage form, and at least one polymeric...

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Hauptverfasser:	McLaughlin, Rosaleen Theresa, Masto, Emilie, Wong, Yik Teng, Barrat, Niamh, Banbury, Susan Gerrard, Garrett, Lisa
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	McLaughlin, Rosaleen Theresa Masto, Emilie Wong, Yik Teng Barrat, Niamh Banbury, Susan Gerrard Garrett, Lisa
description	Disclosed herein is a solid lyophilized vaginal dosage form that can have an effective amount of at least one active ingredient, a crystalline structure forming agent in an amount of about 5 wt. % to about 40 wt. %, based on the total weight of the lyophilized dosage form, and at least one polymeric mucoadhesive matrix forming agent. The dosage form can have a pH of about 4.0 to 5.0, and can disintegrate within 120 seconds after being contacted with a vaginal mucosa. A method of delivering an active ingredient to the vaginal mucosa using the disclosed solid dosage form is also described.
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subjects	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	Lyophilized pharmaceutical compositions for vaginal delivery
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