Pyrimidinone derivatives as Cdc7 inhibitors
The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the tr...
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| creator | Ott, Gregory R Fowler, Katherine M Elustondo, Frederic Charles, Mark David Brookfield, Joanna L Carswell, Emma L Calder, Mathew L Ekwuru, Chukuemeka Tennyson Ford, Daniel James Roffey, Jonathan R |
| description | The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated. |
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The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210601&DB=EPODOC&CC=US&NR=11020396B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210601&DB=EPODOC&CC=US&NR=11020396B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Ott, Gregory R</creatorcontrib><creatorcontrib>Fowler, Katherine M</creatorcontrib><creatorcontrib>Elustondo, Frederic</creatorcontrib><creatorcontrib>Charles, Mark David</creatorcontrib><creatorcontrib>Brookfield, Joanna L</creatorcontrib><creatorcontrib>Carswell, Emma L</creatorcontrib><creatorcontrib>Calder, Mathew L</creatorcontrib><creatorcontrib>Ekwuru, Chukuemeka Tennyson</creatorcontrib><creatorcontrib>Ford, Daniel James</creatorcontrib><creatorcontrib>Roffey, Jonathan R</creatorcontrib><title>Pyrimidinone derivatives as Cdc7 inhibitors</title><description>The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Pyrimidinone derivatives as Cdc7 inhibitors |
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