Fusions of antibodies to CD38 and attenuated interferon alpha

The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which r...

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Hauptverfasser: Wilson, Jr., David S, Tran, Stephen, Pogue, Sarah L, Pollard, Matthew, Taura, Tetsuya, Mikesell, Glen E, Doyle, Anthony G, Lin, Jack Tzu Chiao, Korver, Wouter, Clarke, Adam
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creator Wilson, Jr., David S
Tran, Stephen
Pogue, Sarah L
Pollard, Matthew
Taura, Tetsuya
Mikesell, Glen E
Doyle, Anthony G
Lin, Jack Tzu Chiao
Korver, Wouter
Clarke, Adam
description The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Fusions of antibodies to CD38 and attenuated interferon alpha
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