Precursor compound of radioactive halogen-labeled organic compound
It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [ 18 F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced th...
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| creator | Toyama, Masahito Hayashi, Akio Harano, Arinori Ito, Osamu Shinmura, Toshiyuki Kurosaki, Fumie |
| description | It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [ 18 F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula:
wherein n is an integer of 0 or of 1 to 4; R 1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by -OR 2 ; R 2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R 3 is a protective group. |
| format | Patent |
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wherein n is an integer of 0 or of 1 to 4; R 1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by -OR 2 ; R 2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R 3 is a protective group.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMISTRY ; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY ; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR ; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210323&DB=EPODOC&CC=US&NR=10953112B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210323&DB=EPODOC&CC=US&NR=10953112B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Toyama, Masahito</creatorcontrib><creatorcontrib>Hayashi, Akio</creatorcontrib><creatorcontrib>Harano, Arinori</creatorcontrib><creatorcontrib>Ito, Osamu</creatorcontrib><creatorcontrib>Shinmura, Toshiyuki</creatorcontrib><creatorcontrib>Kurosaki, Fumie</creatorcontrib><title>Precursor compound of radioactive halogen-labeled organic compound</title><description>It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [ 18 F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula:
wherein n is an integer of 0 or of 1 to 4; R 1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by -OR 2 ; R 2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R 3 is a protective group.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY</subject><subject>DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR</subject><subject>DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAKKEpNLi0qzi9SSM7PLcgvzUtRyE9TKEpMycxPTC7JLEtVyEjMyU9PzdPNSUxKzUkFShelJ-ZlJsPV8zCwpiXmFKfyQmluBkU31xBnD93Ugvz41OKCxOTUvNSS-NBgQwNLU2NDQyMnI2Ni1AAAhVcyrw</recordid><startdate>20210323</startdate><enddate>20210323</enddate><creator>Toyama, Masahito</creator><creator>Hayashi, Akio</creator><creator>Harano, Arinori</creator><creator>Ito, Osamu</creator><creator>Shinmura, Toshiyuki</creator><creator>Kurosaki, Fumie</creator><scope>EVB</scope></search><sort><creationdate>20210323</creationdate><title>Precursor compound of radioactive halogen-labeled organic compound</title><author>Toyama, Masahito ; Hayashi, Akio ; Harano, Arinori ; Ito, Osamu ; Shinmura, Toshiyuki ; Kurosaki, Fumie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US10953112B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2021</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY</topic><topic>DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR</topic><topic>DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Toyama, Masahito</creatorcontrib><creatorcontrib>Hayashi, Akio</creatorcontrib><creatorcontrib>Harano, Arinori</creatorcontrib><creatorcontrib>Ito, Osamu</creatorcontrib><creatorcontrib>Shinmura, Toshiyuki</creatorcontrib><creatorcontrib>Kurosaki, Fumie</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Toyama, Masahito</au><au>Hayashi, Akio</au><au>Harano, Arinori</au><au>Ito, Osamu</au><au>Shinmura, Toshiyuki</au><au>Kurosaki, Fumie</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Precursor compound of radioactive halogen-labeled organic compound</title><date>2021-03-23</date><risdate>2021</risdate><abstract>It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [ 18 F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula:
wherein n is an integer of 0 or of 1 to 4; R 1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by -OR 2 ; R 2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R 3 is a protective group.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Precursor compound of radioactive halogen-labeled organic compound |
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