Anti-BAFFR antibody formulations and methods of use thereof

Anti-BAFFR antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration of the antibody active ingredient for delivery to a patient without high levels of antibody aggregation. The lyophilisate can be reconstitut...

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Hauptverfasser: Schaadt, Eveline, Heusser, Christoph, Neugebauer, Julia, Woisetschlaeger, Maximilian, Cosenza, Marta, Urlinger, Stefanie
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creator Schaadt, Eveline
Heusser, Christoph
Neugebauer, Julia
Woisetschlaeger, Maximilian
Cosenza, Marta
Urlinger, Stefanie
description Anti-BAFFR antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration of the antibody active ingredient for delivery to a patient without high levels of antibody aggregation. The lyophilisate can be reconstituted with an aqueous reconstituent to provide an aqueous composition in which the antibody has a concentration of at least 50 mg/ml. The lyophilisate or aqueous pharmaceutical composition may include one or more of a sugar, a buffering agent, a surfactant, and/or a free amino acid.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Anti-BAFFR antibody formulations and methods of use thereof
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