Fermentation process using yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol

Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactat...

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Bibliographische Detailangaben
Hauptverfasser:	Rush, Brian J, Hause, Benjamin Matthew, Roberg-Perez, Kevin, Suominen, Pirrko, Koivuranta, Kari, Aristidou, Aristos, McMullin, Thomas William, Dundon, Catherine Asleson
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CONSTRUCTION OF ROADS, RAILWAYS, OR BRIDGES CONVEYING CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FIXED CONSTRUCTIONS HANDLING THIN OR FILAMENTARY MATERIAL MACHINES FOR MAKING RAILWAYS OF ALL KINDS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PACKING PERFORMING OPERATIONS PERMANENT WAY PERMANENT-WAY TOOLS PNEUMATIC TUBE CONVEYORS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SHOP CONVEYOR SYSTEMS SPIRITS STORING TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING ORTIPPING TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.