Inhibitors of influenza viruses replication
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a c...
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| creator | Gu, Wenxin Deng, Hongbo Wang, Tiansheng Bethiel, Randy S Kennedy, Joseph M Charifson, Paul S Ledeboer, Mark W Clark, Michael P Ledford, Brian Perola, Emanuele Bandarage, Upul K Boyd, Michael J Farmer, Luc J Duffy, John P Maltais, Francois Davies, Ioana Gao, Huai |
| description | Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ):
or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. |
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or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.</description><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201229&DB=EPODOC&CC=US&NR=10875855B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201229&DB=EPODOC&CC=US&NR=10875855B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Gu, Wenxin</creatorcontrib><creatorcontrib>Deng, Hongbo</creatorcontrib><creatorcontrib>Wang, Tiansheng</creatorcontrib><creatorcontrib>Bethiel, Randy S</creatorcontrib><creatorcontrib>Kennedy, Joseph M</creatorcontrib><creatorcontrib>Charifson, Paul S</creatorcontrib><creatorcontrib>Ledeboer, Mark W</creatorcontrib><creatorcontrib>Clark, Michael P</creatorcontrib><creatorcontrib>Ledford, Brian</creatorcontrib><creatorcontrib>Perola, Emanuele</creatorcontrib><creatorcontrib>Bandarage, Upul K</creatorcontrib><creatorcontrib>Boyd, Michael J</creatorcontrib><creatorcontrib>Farmer, Luc J</creatorcontrib><creatorcontrib>Duffy, John P</creatorcontrib><creatorcontrib>Maltais, Francois</creatorcontrib><creatorcontrib>Davies, Ioana</creatorcontrib><creatorcontrib>Gao, Huai</creatorcontrib><title>Inhibitors of influenza viruses replication</title><description>Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ):
or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND2zMvITMosyS8qVshPU8jMS8spTc2rSlQoyywqLU4tVihKLcjJTE4syczP42FgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8aHBhgYW5qYWpqZORsbEqAEApK4qOw</recordid><startdate>20201229</startdate><enddate>20201229</enddate><creator>Gu, Wenxin</creator><creator>Deng, Hongbo</creator><creator>Wang, Tiansheng</creator><creator>Bethiel, Randy S</creator><creator>Kennedy, Joseph M</creator><creator>Charifson, Paul S</creator><creator>Ledeboer, Mark W</creator><creator>Clark, Michael P</creator><creator>Ledford, Brian</creator><creator>Perola, Emanuele</creator><creator>Bandarage, Upul K</creator><creator>Boyd, Michael J</creator><creator>Farmer, Luc J</creator><creator>Duffy, John P</creator><creator>Maltais, Francois</creator><creator>Davies, Ioana</creator><creator>Gao, Huai</creator><scope>EVB</scope></search><sort><creationdate>20201229</creationdate><title>Inhibitors of influenza viruses replication</title><author>Gu, Wenxin ; Deng, Hongbo ; Wang, Tiansheng ; Bethiel, Randy S ; Kennedy, Joseph M ; Charifson, Paul S ; Ledeboer, Mark W ; Clark, Michael P ; Ledford, Brian ; Perola, Emanuele ; Bandarage, Upul K ; Boyd, Michael J ; Farmer, Luc J ; Duffy, John P ; Maltais, Francois ; Davies, Ioana ; Gao, Huai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US10875855B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Gu, Wenxin</creatorcontrib><creatorcontrib>Deng, Hongbo</creatorcontrib><creatorcontrib>Wang, Tiansheng</creatorcontrib><creatorcontrib>Bethiel, Randy S</creatorcontrib><creatorcontrib>Kennedy, Joseph M</creatorcontrib><creatorcontrib>Charifson, Paul S</creatorcontrib><creatorcontrib>Ledeboer, Mark W</creatorcontrib><creatorcontrib>Clark, Michael P</creatorcontrib><creatorcontrib>Ledford, Brian</creatorcontrib><creatorcontrib>Perola, Emanuele</creatorcontrib><creatorcontrib>Bandarage, Upul K</creatorcontrib><creatorcontrib>Boyd, Michael J</creatorcontrib><creatorcontrib>Farmer, Luc J</creatorcontrib><creatorcontrib>Duffy, John P</creatorcontrib><creatorcontrib>Maltais, Francois</creatorcontrib><creatorcontrib>Davies, Ioana</creatorcontrib><creatorcontrib>Gao, Huai</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Gu, Wenxin</au><au>Deng, Hongbo</au><au>Wang, Tiansheng</au><au>Bethiel, Randy S</au><au>Kennedy, Joseph M</au><au>Charifson, Paul S</au><au>Ledeboer, Mark W</au><au>Clark, Michael P</au><au>Ledford, Brian</au><au>Perola, Emanuele</au><au>Bandarage, Upul K</au><au>Boyd, Michael J</au><au>Farmer, Luc J</au><au>Duffy, John P</au><au>Maltais, Francois</au><au>Davies, Ioana</au><au>Gao, Huai</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Inhibitors of influenza viruses replication</title><date>2020-12-29</date><risdate>2020</risdate><abstract>Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ):
or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Inhibitors of influenza viruses replication |
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