Polymorph of triaryldimethylpiperazine dihydrochloride and preparation method and application thereof

The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament f...

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Bibliographische Detailangaben
Hauptverfasser:	Su, Mei, Wang, Zeren, Yang, Zhi, Zhang, Tiancai, Zhao, Chunmei, Shi, Bing, Mao, Yong, Zhu, Zhaoyun, Zhang, Kuanren, Liu, Yong, Liu, Hongbin, Li, Zeqian, Wang, Jingkun, Song, He, Liu, Huilang, Sun, Min, Su, Min, Yuan, Fang, Cui, Tao, Shen, Yuehai, Wei, Yunlin
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a δ opioid receptor.