Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease

The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical...

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Bibliographische Detailangaben
Hauptverfasser: Aicher, Thomas D, VanHuis, Chad A, Taylor, Clarke B
Format: Patent
Sprache:eng
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Zusammenfassung:The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.