Method of using antibody polypeptides that antagonize CD40 to treat IBD

Method of using antibody polypeptides that antagonize CD40 to treat IBD

A method of treating an inflammatory bowel disease is provided. The method comprises administration of an antibody polypeptide that specifically binds a novel epitope of human CD40. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides may be fusions of a domain a...

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Hauptverfasser: Suchard, Suzanne J, Gustavson, Linda M, Shi, Rong, Honczarenko, Marek, Price, Karen D, Liu, Xiaoni, Trigona, Wendy L, Shah, Vaishali
Format: Patent
Sprache:eng
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator Suchard, Suzanne J
Gustavson, Linda M
Shi, Rong
Honczarenko, Marek
Price, Karen D
Liu, Xiaoni
Trigona, Wendy L
Shah, Vaishali
description A method of treating an inflammatory bowel disease is provided. The method comprises administration of an antibody polypeptide that specifically binds a novel epitope of human CD40. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides may be fusions of a domain antibody (dAb) comprising a single VL or VH domain and an Fc domain.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Method of using antibody polypeptides that antagonize CD40 to treat IBD
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