Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate

Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate

Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.

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Hauptverfasser: Ricci, Antonio, Stivanello, Mariano, Huber, Florian Anton Martin
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator Ricci, Antonio
Stivanello, Mariano
Huber, Florian Anton Martin
description Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.
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METALLURGY
ORGANIC CHEMISTRY
title Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate
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