Methods of inducing responsiveness to anti-angiogenic agent

The invention provides methods of inducing or improving responsiveness to a VEGF antagonist to a subject or a subject population comprising administering an adenovirus comprising a nucleic acid construct comprising a F AS-chimera gene operably linked to an endothelial cell-specific promoter and admi...

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Bibliographische Detailangaben
Hauptverfasser: Feige, Erez, Sher, Naamit, Leubitz, Andrea Rachel, Breitbart, Eyal
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention provides methods of inducing or improving responsiveness to a VEGF antagonist to a subject or a subject population comprising administering an adenovirus comprising a nucleic acid construct comprising a F AS-chimera gene operably linked to an endothelial cell-specific promoter and administering the VEGF antagonist.