Systems and methods for automated, customizable sample preparation for detection of metabolites and lipids
Described herein are automated and customizable sample preparation and analysis systems for detection and quantification of biomarkers (e.g., metabolites and/or lipids) in biological samples (e.g., blood, serum, or plasma) in a clinical setting. The automated systems are controlled by scripts that i...
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| creator | Martinez-Barea, Juan Rossell, Andreu Fabregat Martinez, Rosa Argamasilla Castillo, Paola Hurtado Hense, Christian Bitenc, Marko Kruusmaa, Kristi Gomez, Antonio Jesus Adsuar Gómez, Patricia Rodríguez Girón, Ana María Jiménez |
| description | Described herein are automated and customizable sample preparation and analysis systems for detection and quantification of biomarkers (e.g., metabolites and/or lipids) in biological samples (e.g., blood, serum, or plasma) in a clinical setting. The automated systems are controlled by scripts that integrate communication between the components of the sample preparation system. Also described herein are mass spectrometry-based analytical methods featuring efficient system calibration and sample analysis that provide for accurate quantification of a set of markers in biological samples. The methods are capable of automatic high sample throughput in a clinical setting for detection and quantification using a mass spectrometry system and high performance liquid chromatography column. |
| format | Patent |
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| subjects | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING |
| title | Systems and methods for automated, customizable sample preparation for detection of metabolites and lipids |
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